Walter Cannon discovered acute stress response in 1915 when he noticed the manifestation of nervous exhaustion as physical illness in soldiers of World War I.įurthermore, Hans Seyle described the general adaptation syndrome in 1936, stating that when in distress, the physiological systems are functionally compromised. Mervyn discusses the evolution of various theories associated with stress. These stresses include old age, co-morbidities, prolonged critical illness, modern lifesaving drugs, and organ support.
Human bodies are not designed to cope with the stresses of prolonged life. These include inflammatory, immune, cardiovascular, respiratory and metabolic systems. These mechanisms include changes in behaviour, as well as autonomic and hormonal modulation of various systems. Stress is a normal coping mechanism which helps to deal with the various stressors we encounter. Stress might cause functional damage rather than structural damage. Often, the organs involved in multi-organ failure show no signs of structural damage or cell damage that would indicate these organs might be under stress. In this podcast, Mervyn Singer talks about the link between stress and multiple organ failure. Stress Metabolism Adaptation & Critical Illness: Mervyn Singer
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